Hepatic Deletion of Janus Kinase 2 Counteracts Oxidative Stress in Mice
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چکیده
منابع مشابه
Hepatic Deletion of Janus Kinase 2 Counteracts Oxidative Stress in Mice
Genetic deletion of the tyrosine kinase JAK2 or the downstream transcription factor STAT5 in liver impairs growth hormone (GH) signalling and thereby promotes fatty liver disease. Hepatic STAT5 deficiency accelerates liver tumourigenesis in presence of high GH levels. To determine whether the upstream kinase JAK2 exerts similar functions, we crossed mice harbouring a hepatocyte-specific deletio...
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1 Department of Cellular Biology and Anatomy, LSU Health Sciences Center Shreveport, LA 71103, USA 2Department of Pathology, University of Alabama at Birmingham, AL 35233, USA 3 Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, USA 4Environmental Health and Disease Laboratory, University of South Carolina, Columbia, NC 27709, USA 5National Primate Re...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep34719